L-2-hydroxyglutaric acid (L-2-HGA) adhduria is an inherited metabolic disorder that leads to the accumulation of abnormal metabolites in the dog’s body, particularly in the nervous system. A mutation in the gene responsible for L-2-hydroxyglutaric acid metabolism results in excessive accumulation of L-2-hydroxyglutaric acid, causing damage to brain cells.
Symptoms of the disease usually appear at a young age and are progressive. They may be subtle at first, but over time they lead to pronounced neurological abnormalities and deterioration of the animal’s quality of life.
Advanced DNA analysis helps to better understand genetic predispositions and make informed decisions about animal health. The PetGen study analyzes genetic variants associated with the risk of selected inherited and polygenic diseases. The result provides valuable information about the animal’s health predispositions, supporting prevention, planning further diagnostics and daily care. It’s a tool that helps owners, breeders and veterinarians act earlier and more deliberately.
